Intrarenal Dopaminergic System Regulates Renin Expression
نویسندگان
چکیده
منابع مشابه
Intrarenal dopaminergic system regulates renin expression.
Dopamine is a major regulator of proximal tubule salt reabsorption and is a modulator of renin release. Dopamine has been reported to stimulate renin release in vitro through activation of D1-like receptors. However, previous studies investigating dopamine regulation of renin release in vivo have provided contradictory results, indicating stimulation, inhibition, or no effect. We have reported ...
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Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen 8 University, Guangzhou, China 510080 9 Department of Orthopedics, The 5 Affiliated Hospital, Sun Yat-sen University, 10 Zhuhai, China 519000 11 Department of Medicine, Division of Hypertension and Renal Diseases, 12 University of Colorado Denver, Aurora, CO, USA 80010 13 Department of Medicine, Division of Renal Diseases and ...
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Recent interest focuses on urinary renin and angiotensinogen as markers of renal renin-angiotensin system activity. Before concluding that these components are independent markers, we need to exclude that their presence in urine, like that of albumin (a protein of comparable size), is due to (disturbed) glomerular filtration. This review critically discusses their filtration, reabsorption and l...
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BACKGROUND We recently reported that immunoreactivity of intrarenal angiotensinogen (AGT) is significantly increased in IgA nephropathy patients. Meanwhile, we have developed direct enzyme-linked immunosorbent assays to measure plasma and urinary AGT (UAGT) in humans. This study was performed to test the hypothesis that UAGT levels are increased in chronic glomerulonephritis patients. METHODS...
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T he renin–angiotensin system (RAS) is a coordinated hormonal cascade critical to the control of renal sodium (Na +) excretion and blood pressure (BP). 1 Angiotensin II (Ang II), the principal RAS effector peptide, binds to 2 distinct receptors, the Ang type-1 receptor (AT 1 R) and the Ang type-2 receptor (AT 2 R) with high affinity. The vast majority of actions of Ang II are transmitted via AT...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2009
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.108.127035